; having said that, further molecular studies are required to investigate the mechanism underlying the antihypercholesterolemic effect of this compound. Future research need to focus around the hypolipidemic effect of eugenol beneath circumstances of chronic hypercholesterolemia.Conflict of InterestsThe authors declare that there is absolutely no conflict of interests.AcknowledgmentsFinancial help offered by University Grants Commission-Basic Scientific Analysis (UGC-BSR) within the kind of one time grant to the corresponding author is gratefully acknowledged. The instrumentation facility provided by the University Grants Commission-Special Help Programme (UGC-SAP) of the Department of Animal Science, Bharathidasan University, can also be acknowl-edged. The authors thank Dr. S. Pannerselvam, Professor and Head, Sugarcane10 Analysis Station, Sirugam-ani-Tiruchirappalli, Tamilnadu, India, for giving the Piper betle range.Evidence-Based Complementary and Option Medicine[15] Globe Health Organization, “FAO/WHO expert committee on meals additives evaluation of particular meals additives and contaminants,” Tech. Rep. 683, WHO, Geneva, Switzerland, 1982. [16] A. M. Rimando, B. H. Han, J. H. Park, and M. C. Cantoria, “Studies on the constituents of Philippine Piper betle leaves,” Archives of Pharmacal Study, vol. 9, no. 2, pp. 93?7, 1986. [17] A. Manigauha, S. Patel, H. Ali, A. Chandy, and M. Uma Maheshwari, “Study the effect of phytochemical constituents of Piper betle leaves extracts on liver problems by in vivo model,” Journal of Pharmacy Research, vol. 2, pp. 353?56, 2009. [18] P. E. Schurr, J. R. Schultz, and T. M. Parkinson, “Triton-induced hyperlipidemia in rats as an animal model for screening hypolipidemic drugs,” Lipids, vol. 7, no. 1, pp. 68?four, 1972. [19] M. M. Bradford, “A rapid and sensitive strategy for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding,” Analytical Biochemistry, vol. 72, no. 1-2, pp. 248?54, 1976. [20] T. Sasaki, S. Matzy, along with a. Sonal, “Effect of acetic acid concentration on the colour reaction in the O-toluidine boric acid system for blood glucose estimation,” Rinsho Kagaku, vol. 1, pp. 346?53, 1972. [21] W. T. Friedewald, R. I. Levy, and D. S. Fredrickson, “Estimation with the concentration of low-density lipoprotein cholesterol in plasma, devoid of use on the preparative ultracentrifuge,” Clinical Chemistry, vol. 18, no. six, pp. 499?02, 1972. [22] J.819050-89-0 Data Sheet King, “The transferases-alanine and aspartate transaminases,” in Practical Clinical Enzymology, D. Van, Ed., pp. 121?38, D. Van Nostrand, London, UK, 1965. [23] J. King, “The hydrolases-acid and alkaline phosphatases,” in Practical Clinical Enzymology, D.1-Methyl-1H-imidazole-4-carbaldehyde uses Van, Ed.PMID:24957087 , pp. 191?08, D. Van Nostrand, London, UK, 1965. [24] J. King, “The dehydrogenases or oxidoreductases lactate dehydrogenase,” in Sensible Clinical Enzymology, D. Van, Ed., D. Van Nostrand, London, UK, 1965. [25] A. K. Sinha, “Colorimetric assay of catalase,” Analytical Biochemistry, vol. 47, no. 2, pp. 389?94, 1972. [26] S. Marklund and G. Marklund, “Involvement on the superoxide anion radical in the autoxidation of pyrogallol and a handy assay for superoxide dismutase,” European Journal of Biochemistry, vol. 47, no. three, pp. 469?74, 1974. [27] J. T. Rotruck, A. L. Pope, H. E. Ganther, A. B. Swanson, D. G. Hafeman, and W. G. Hoekstra, “Selenium: biochemical part as a element of glatathione peroxidase,” Science, vol. 179, no. 4073, pp. 588?90, 1973. [28] W. H. Habig and W. B. J.