D CM. WG provided SVV BAC and WT SVV. All authors study and authorized the final manuscript. Acknowledgements We would prefer to thank the Division of Animal Resources (DAR) at the Oregon National Primate Research Center for specialist animal care, in particular Drs. Anne Lewis and Lois Colgin for conducting the necropsies and collecting tissues; Alfred Legasse, Miranda Fischer and Shannon Planer for collection of blood and BAL samples. This perform was supported by American Heart Association profession improvement grant 0930234N, NIH R01AG037042, 2T32AI007472-16, NIH 8P51 OD011092-53 and also the Brookdale Foundation. The funding sources had no role in study style, data collection and analysis, decision to publish, or preparation from the manuscript. Author information 1 Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Beaverton, OR 97006, USA. 2Molecular Microbiology and Immunology Department, Oregon National Primate Research Center, Beaverton, OR 97006, USA. 3Division of Pathobiology and Immunology, Oregon National Primate Study Center, Beaverton, OR 97006, USA. 4Division of Biomedical Sciences, University of California-Riverside, Riverside, CA 92508, USA. 5Department of Microbiology and Immunology, University of Arkansas, Little Rock, AK 72205, USA. 6School of Medicine, University of California-Riverside, 900 University Avenue, Riverside, CA 92521, USA.BAL cells and PBMC have been surface stained with antibodies against 1) CD4 (eBioscience, San Diego CA), CD8 (Beckman Coulter), CD28, and CD95 (BioLegend, San Diego CA) to delineate the naive (CD28+CD95-), central memory (CD28+CD95+), and effector memoryMeyer et al. Virology Journal 2013, 10:278 http://virologyj/content/10/1/Page 11 ofReceived: 10 July 2013 Accepted: three September 2013 Published: eight September 2013 References 1. Oxman MN, Levin MJ: Vaccination against herpes zoster and postherpetic neuralgia. J Infect Dis 2008, 197(Suppl 2):S228 236. two. Oxman MN, et al: A vaccine to stop herpes zoster and postherpetic neuralgia in older adults. N Engl J Med 2005, 352(22):2271?284. 3. Clarkson MJ, Thorpe E, McCarthy K: A virus disease of captive vervet monkeys (Cercopithecus aethiops) brought on by a brand new herpesvirus. Arch Gesamte Virusforsch 1967, 22(1):219?34. 4. Mahalingam R, et al: Simian varicella virus DNA in dorsal root ganglia. Proc Natl Acad Sci USA 1991, 88(7):2750?752. 5. Messaoudi I, et al: Simian varicella virus infection of rhesus macaques recapitulates vital features of varicella zoster virus infection in humans.2,3-Dibromo-4-methylpyridine web PLoS Pathog 2009, five(11):e1000657.55241-49-1 Chemical name 6.PMID:25027343 Fletcher TM 3rd, Gray WL: DNA sequence and genetic organization of the one of a kind short (US) region in the simian varicella virus genome. Virology 1993, 193(two):762?73. 7. Gray WL, et al: The simian varicella virus and varicella zoster virus genomes are similar in size and structure. Virology 1992, 186(2):562?72. eight. Gray WL, et al: The DNA sequence with the simian varicella virus genome. Virology 2001, 284(1):123?30. 9. Gray WL, Oakes JE: Simian varicella virus DNA shares homology with human varicella-zoster virus DNA. Virology 1984, 136(1):241?46. ten. Davison AJ, Scott JE: The comprehensive DNA sequence of varicella-zoster virus. J Gen Virol 1986, 67(Pt 9):1759?816. 11. Gray WL, et al: Cloning the simian varicella virus genome in E. coli as an infectious bacterial artificial chromosome. Arch Virol 2011, 156(five):739?46. 12. Gray WL, et al: Simian varicella virus gene 61 encodes a viral transactivator but is non-essential for in vitro replicati.
